PROSPERO is an international systematic review registry that prospectively registers systematic reviews protocols, creates publicly available registration records and issues a unique registration number for each registered review protocol.
PROSPERO, an initiative of CRD at the University of York, was made available in 2011 and has been funded by the NIHR in the UK since inception. The current version of PROSPERO was launched in February 2025.
PROSPERO aims to promote transparency and open science, reduce reporting bias and help prevent unintended duplication and research waste. There is no charge for using PROSPERO; it is free to register and free to search.
PROSPERO includes two registries, the original registry of systematic reviews of studies that involve human participants and relate directly to human health and PROSPERO4animals which registers systematic reviews of studies involving animal participants and which relate to human health. Both operate on the same platform but have different management and processing arrangements.
